Some substituted derivatives of 2-pyridone of pharmacological interest.1968.
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Some substituted derivatives of 2-pyridone of pharmacological interest.1968.

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Published .
Written in English


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Ph.D. thesis of the University of London.

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Open LibraryOL13659938M

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The synthesis of some 5-cyanohydroxypyridone derivatives (3 a–c) by condensation of 3-aminocrotononitrile (1) with substituted diethylmalonates (2 a–c) is described. Design and synthesis of novel pyridin-2(1H)-one derivatives and evaluation of their anticancer activity 6 Trichoderma harzianum as a racemic mixture, reported to have a significant antifungal activity Other 2-pyridone derivatives, Apiosporamide (28) and its oxidized congener YM (29) isolated from the fungus Apiospora montagnei and Phoma sp. found to. N-substitutedpyridone derivatives have many pharmaceutical properties. In our research, we have developed an efficient, green, and multicomponent protocol to synthesize such new fused N. A series of new 4,6-disubstitutedcyanopyridone derivatives (4a-o) were synthesized. The structures of all target molecules (4a-o) have been confirmed by various spectral techniques and.

A series of variously substituted 5-carboxymethyl-3,4-dihydro-2(1H)-pyridone derivatives were synthesized and their oxidation potentials determined by cyclic voltammetry. The resulting 2-pyridone structure and a tricyclic heterocycle which was formed during an attempted synthesis of 4-(2-hydroxyphenyl) substituted 3,4-dihydro-2(1H)-pyridone were confirmed by single crystal X-ray . The structure-based design, chemical synthesis, and biological evaluation of various 2-pyridone-containing human rhinovirus (HRV) 3C protease (3CP) inhibitors are described. These compounds are comprised of a peptidomimetic binding determinant and a Michael acceptor moiety, which forms an irreversible covalent adduct with the active site cysteine residue of the 3C enzyme. The 2-pyridone. A series of functionalized 2-pyridone derivatives are efficiently and eco-friendly obtained by multicomponent reaction of several chromene derivatives with . The design, synthesis, and biological activity of benzimidazolecarboxylic acids bearing 5-oxo-1,2,4-oxadiazole, 5-oxo-1,2,4-thiadiazole, 5-thioxo-1,2,4-oxadiazole, and 2-oxo-1,2,3,5-oxathiadiazole rings are described. These compounds were efficiently prepared from the key intermediates, the amidoximes 4. The synthesized compounds were evaluated for in vitro and in vivo angiotensin II (AII.

Targeted 2-pyridones were selected as tissue Factor VIIa inhibitors and prepared from 2,6-dibromopyridine via a multistep synthesis. A variety of chemical transformations, including regioselective nucleophilic addition, selective nitrogen alkylation, and a Suzuki coupling, afforded the targeted tissue Factor VIIa inhibitors. The pyridone core was selected as a replacement for the pyrazinone. KF/Alumina catalyzed synthesis of ester functionalized 2-Pyridone derivatives 16 very hard anion (F-ion), which possibly augments the surface to be act as a potential base and differentiate from other alkaline earth metal oxide base catalysts in affording the target molecules 2. Request PDF | ChemInform Abstract: The 2-Pyridone Antibacterial Agents: Bacterial Topoisomerase Inhibitors | Many attempts have been made to prepare analogs of 4-quinolone antibacterial agents. The previously unknown fused 2-pyridone derivatives containing the 4-aminopyridine fragment were synthesized by the Knoevenagel reaction. New approach to the synthesis of 4-aminopyridone and 1-phenyl-1,6-naphthyridinone derivatives based on substituted 3-and 5-formylpyridones | SpringerLink.