|Statement||edited by John A. Kanis.|
|Contributions||Kanis, John A.|
Christopher S. Kovacs, in Genetics of Bone Biology and Skeletal Disease, Calcitonin Deficiency. Calcitonin deficiency during lactation caused Ctcgrp null mice to lose twice the normal amount of bone mineral content during lactation but they fully restore it after weaning. 9 These findings indicate that physiological levels of calcitonin protect at least the rodent skeleton from excessive. Calcitonin is a peptide composed of 32 amino acids that binds to osteoclasts and inhibits bone resorption [ 1,2 ]. Calcitonins from many species are effective in humans, but salmon calcitonin is the one most widely used. It is highly potent in humans because of its high affinity (40 times that of human calcitonin) for the human calcitonin. The European Medicines Agency (EMA) recommended that calcitonin be used only on a short-term basis for 3 conditions for which it had previously been approved in the European Union: Paget's disease, acute bone loss resulting from sudden immobilization, and hypercalcemia caused by cancer. As a solution for injection or infusion, calcitonin should Pronunciation: "Paget" /ˈpædʒɪt/. Calcitonin is also useful in the treatment of other bone diseases such as Paget’s disease, where the renewal and repair cycle in bone is disrupted, leading to large and malformed bones.
Calcitonin is a man-made form of a hormone that occurs naturally in the thyroid gland. Calcitonin injection is used to treat Paget's disease of bone, or high levels of calcium in the blood 1/5. Calcitonin. Calcitonin is a hormone known to participate in calcium and phosphorus metabolism. In mammals, the major source of calcitonin is from the parafollicular or C cells in the thyroid gland, but it is also synthesized in a wide variety of other tissues, including the lung and intestinal birds, fish and amphibians, calcitonin is secreted from the ultimobrachial glands. Calcitonin inhibits bone removal by the osteoclasts and at the same time promotes bone formation by the osteoblasts. Calcitonin is given in hypercalcemia (high blood calcium) to lower the calcium level; in osteoporosis to increase bone density and decrease the risk of a fracture ; and in Paget disease to decrease bone turnover and bone pain. The agents currently available in the United States for treatment of osteoporosis, estrogens and salmon calcitonin, primarily stabilize bone mass and prevent further loss of bone, although a.
Calcitonin is a synthetic hormone, given as an injection, and a naturally occurring hormone in humans that is involved in calcium regulation and phosphate metabolism. Sometimes calcitonin is also used in the treatment of Paget disease, osteoporosis, and other benign bone diseases. is a rapid access, point-of-care medical reference for primary care and emergency clinicians. Started in , this collection now contains interlinked topic pages divided into a tree of 31 specialty books and chapters. An advantage of calcitonin that is not shared by other antiresorptive therapies is its direct analgesic effect on bone pain. Calcitonin has been demonstrated to be clinically useful in improving pain, not only from the acute vertebral fractures of osteoporosis, but also in Pagets disease, bone malignancies, and other sources of musculoskeletal. Paget’s disease can affect any bone in the human body. These include: pelvic bones, hip joint, skull, vertebral bones, bones of the arm and forearm, bones in the trunk, bones of the thigh and legs. Many people with Paget’s disease associated arthritis tend to complain more of .